Abstract
Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.4] and hyaluronidase [E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemical synthesis
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / pharmacology
-
Benzoates / chemical synthesis
-
Benzoates / chemistry*
-
Benzoates / pharmacology*
-
Elapidae
-
Enzyme Inhibitors / chemical synthesis*
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology*
-
Hyaluronoglucosaminidase / antagonists & inhibitors*
-
Hyaluronoglucosaminidase / metabolism
-
Inhibitory Concentration 50
-
Mice
-
Molecular Structure
-
Phospholipases A / antagonists & inhibitors*
-
Phospholipases A / metabolism
-
Phospholipases A2
-
Structure-Activity Relationship
-
Viperidae
Substances
-
Anti-Inflammatory Agents
-
Benzoates
-
Enzyme Inhibitors
-
Phospholipases A
-
Phospholipases A2
-
Hyaluronoglucosaminidase